Abstract
Alzheimer’s Disease (AD) has, in recent years, become the focus of intensive research efforts aimed at determining the various factors, as well as their degrees of involvement, in its pathogenesis and progression. Of such factors, the immunocompetent microglial cells have repeatedly been implicated as potentially key contributors to the disease process—having namely garnered much attention from genome-wide association studies, as well as studies conducted using murine models. Despite the versatility and convenience of these models, AD remains a distinctly human condition. The present review aims to consolidate evidence regarding the nature and putative role played by microglial activation in the pathogenesis and progression of AD, as it pertains to the aging human brain.
Citation
Laramee AS and Provias JP. A Human Perspective on the Immunopathology of Microglial Cells in Alzheimer’s Disease. SM J Clin Pathol. 2016; 1(1): 1004.