Abstract
Aim of the work: To detect the presence of Anti-Cyclic-Citrullinated Peptide Antibodies (anti CCP Ab) and Anti-Modified Citrullinated Vimentin Antibodies (anti MCV Ab) in Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc) patients and their correlation to radiological findings and disease activity.
Methods: This study was included 70 SLE patients and 30 SSc patients diagnosed according to ACR classification criteria. After informed consent, all patients were subjected to detailed history taking, full clinical examination including rheumatological examination, laboratory investigations: included CBC, ESR, CRP with titer, urine analysis, renal and liver function, serum uric acid, ANA, Anti dsDNA antibodies by Indirect Immunofluorescence Method (IIF), Anti Scl 70 antibody, Anti CCP and Anti MCV antibodies done by ELISA. X- Ray and U/S on both hands and knees and disease activity score using SLEDAI score for SLE patients and Medsgar score for SSc patients.
Results: In this study, anti CCP Ab were found in 8 (11.4%) of SLE patients and 4 (13.3%) SSc patients, while anti MCV Ab were found in 14 (20%) SLE patients and 8 (26.7%) of SSc patients. There is association between presence of anti CCP Ab and anti MCV Ab and a clinically evident arthritis in both SLE and SSc. Strong relationship between high CRP level and a severe arthritis and joint erosions was noticed in SLE patients. A significant radiological evident erosive arthritis in the form of synovial hypertrophy and bony erosions were found using ultrasonography and plain X-ray with seropositive anti CCP and anti MCV Ab in both SLE and SSc patients. In our study, cut off value of anti CCP which was >12, with sensitivity of 70.42% and specificity of 60%and best cut off value of Anti MCV which was >11, with sensitivity of 98.46% and specificity of 30% in SLE and SSc.
Conclusion: There is a significant association between presence of anti CCP Ab and anti MCV Ab and the presence of clinically and radiologicaly evident erosive arthritis assessed by x-ray and U/S in both SLE and SSc patients.
Citation
Elsayed AM, Mohamed SAER, El-Azizi NO, Ibrahim SI, Abdelzaher A, Mohamed NL, et al. Anti CCP and Anti MCV Antibodies are Marker of Arthritis in Systemic Lupus Erythematosus and Scleroderma. SM J Arthritis Res. 2017; 1(1): 1001