Keywords
Curcuma kwangsiensis; Volatile oil; GC-MS; Inhibitory action; Active ingredients
Abstract
Objective: The experiment intended to analyze chemical components of volatile oil from Curcuma kwangsiensis by GC-MS, and to explore its inhibitory action on the growth of human lung cancer cells.
Methods: Extracted with the steam distillation, chemical compositions of volatile oil from Curcuma kwangsiensis were isolated and identified by GC-MS and computer similarity retrieval. Relative percentage contents of each ingredient were determined with peak area normalization. And active ingredients of Curcuma kwangsiensis were determined its inhibitory action on the growth of human lung cancer cells.
Results: Twenty compounds were identified from volatile oil from Curcuma kwangsiensis. They were almost sesquiterpenes and monoterpenes. The relative percentage content of curzerenone was highest, 4.94 %, followed by eucalyptol, 3.03 %, γ-gurjunenepoxide-(1), 2.03 %, germacrone, 1.8 %, camphor, 1.57 %. The IC50 value of volatile oil from Curcuma kwangsiensis acting on H446 cells was 7.55±0.38 μg/mL.
Conclusion: Compounds of volatile oil from Curcuma kwangsiensis were almost sesquiterpenes and monoterpenes, and volatile oil from Curcuma kwangsiensis had an inhibitory action on the growth of human lung cancer cells, H446 cells.
Citation
Tang S, Lin M, Tan L, Huang W, Ou X, and Zhang J et al., Chemical Components of Volatile Oil from Curcuma Kwangsiensis and Its Growth Inhibition on H446 Cells. SM J Pharmac Ther. 2015; 1(2): 1007.