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SM Journal of Nanotechnology and Nanomedicine

Chemical and Biological Systems of the Activity Oxygen Singlete in the Destruction of Microbial Cells in Photodynamic Therapy

[ ISSN : 3068-0808 ]

Abstract
Details

Received: 25-Sep-2017

Accepted: 09-Nov-2017

Published: 13-Nov-2017

Review Article | Volume 2 - Issue 1 | Article DOI :

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Marisol Porto Rocha, Francine Cristina Silva Rosa* and Luciano Pereira Rosa

Department of Biophotonics Applied to Health, Federal University of Bahia, Brazil

Corresponding Author:

Francine Cristina Silva Rosa, Department of Biophotonics Applied to Health, Federal University of Bahia, Multidisciplinary Institute in Health, Vitoria da Conquista, Bahia-Brazil, Email: drfransilva@yahoo.com.br

Keywords

Singletoxygen; Phototodynamictherapy; PDT; Lethal photosensitization; Microorganism

Abstract

Singlet oxygen (1 O2 ) is an excited form of molecular oxygen that acts as an active agent in antimicrobial Photodynamic Therapy (PDT), a promising technique for the treatment of several types of infections. In this review, we present a summary of the physical-chemical and biological aspects of 1 O2 and the lethal photosensitization mechanisms mediated by it in PDT. The chemical structure of H2 O will be approached through molecular orbital theory. PDT techniques that enhance the formation of this radical using different photosensitizing dyes will also be introduced as well as biological targets of 1 O2 in microbial cells and the obstacles encountered in such structures. This knowledge is crucial to design new research methodologies that increase the chain of reaction of 1 O2 in PDT, consequently, increase the effectiveness of the therapy

Citation

Rocha MP, Rosa FCS and Rosa LP. Chemical and Biological Systems of the Activity Oxygen Singlete in the Destruction of Microbial Cells in Photodynamic Therapy. SM J Nanotechnol Nanomed. 2017; 2(1): 1004.