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SM Journal of Infectious Diseases

Clinical Features, Radiological Findings and Risk Factors of an Acute Febrile Respiratory Disease Caused by Human Adenovirus Type 55, and its Variety during COVID-19 Pandemic

[ ISSN : 3066-134X ]

Abstract
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Received: 14-Aug-2024

Accepted: 11-Sep-2024

Published: 14-Sep-2024

Research Article | Volume 7 - Issue 1 | Article DOI :

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Yanqiong Zhang¹, Hebin Fan¹*, Dong Liang Yang², Wenjia Gui¹, Zhi Li¹, and Qiongshu Wang³

¹Department of Infectious Diseases, the General Hospital of the Central Theater Command of the People’s Liberation Army, Wuhan, Hubei Province, China
²Department of Infectious Diseases, the Xiehe Hospital of Huazhong University of Science and Technology, Wuhan, Hubei Province, China
³Department of Diseases Control, the General Hospital of the Central Theater Command of the People’s Liberation Army, Wuhan, Hubei Province, China

Corresponding Author:

Hebin Fan, Department of Infectious Diseases, the general hospital of the central theater command of the People’s Liberation Army, Wuhan, Hubei Province, China.

Keywords

Adenovirus; Neutrophil-Lymphocyte Count Ratio; Clinical Features

Abstract

Background: The purpose of this study was to identify the clinical and thin-section CT findings in patients with adenovirus infections occurring at a campus, describe the risk factors for progress in pneumonia. The changes during COVID-19 pandemic were also observed.

Methods: From February to April of 2018, clinical data and samples from the patients were collected. We described characteristics of progressed group (n = 97) versus no-progressed group (n = 12) and compared clinic-laboratory between the two groups. From December 2020 to December 2022, all patients with acute respiratory fever on the campus were tested for adenovirus nucleic acid with nasopharyngeal swabs.

Results: The main clinical manifestations of acute febrile respiratory caused by B55 adenovirus infection were fever, cough, sore throat and aching muscles which had no significant difference between two groups. The duration of fever (> 5 days) was significantly different between the two groups (p = 0.000). The dynamic changes of neutrophil-lymphocyte count ratio (NLR) in no-progressed patients were lower than those of progressed patients (P = 0.000). The fever duration (≥ 5 days) (OR = 14.628; 95% CI = 0.009 ± 0.508; p = 0.009) and the NLR changes (OR = 0.47; 95% CI = 0.279 ± 0.797; p = 0.005) remained independent factors associated with progressed disease. Four and five adenovirus nucleic acid positive cases were detected in October 2021 and 2022 respectively.

Conclusion: Adenovirus infection is associated with the decreased peripheral blood lymphocyte proportion. Proper immunomodulatory treatment may be important for these patients. Hand hygiene, social distance and isolation are import means to control respiratory diseases transmitted by airborne droplets.

Citation

Zhang Y, Fan H, Yang DL, Gui W, Li Z. et al. (2024) Clinical Ob servation of 212 Cases of Cervical Low-Grade Squamous Intraepithelial Le sion (LSIL) Treated by Photodynamic Therapy (PDT). SM J Infect Dis 7: 6.