Submit Article
Back to Journal

SM Journal of Neurological Disorders and Stroke

Early Transient Neuronal CyclinD1 Expression Precedes Atrophy in the Frontal Cortex of APP23 Mice

[ ISSN : 3067-9982 ]

Abstract
Details

Received: 03-Sep-2017

Accepted: 29-Sep-2017

Published: 06-Oct-2017

Research Article | Volume 3 - Issue 2 | Article DOI :

Download PDF

Stefania Ippati¹, Claire H Stevens¹, Lars M Ittner¹²*, and Yazi D Ke³

¹Dementia Research Unit, Department of Anatomy, School of Medical Sciences, University of New South Wales, Sydney, Australia
²Neuroscience Research Australia, Sydney, Australia
³Motor Neuron Disease Unit, Department of Anatomy, School of Medical Sciences, University of New South Wales, Sydney, Australia

Corresponding Author:

Lars M Ittner, Dementia Research Unit, Department of Anatomy, School of Medical Sciences,Faculty of Medicine, University of New South Wales, Neuroscience Research Australia, NSW 2052, Sydney, Australia,

Keywords

CyclinD1; PCNA; Alzheimer’s disease; Mouse model; APP; Cell cycle re-entry

Abstract

Alzheimer’s disease (AD), the most common form of dementia, is neuropathologically characterized by the deposition of Amyloid-β (Aβ) in plaques. Interestingly, a significant number of neurons in AD brains display aberrant re-entry of cell cycle and expression of associated proteins. While this has been observed in a number of Aβ Precursor Protein (APP) transgenic mouse models of AD, the temporal and spatial profile of neuronal cell cycle protein expression was unclear. Here, we show that neuronal expression of the cell cycle protein CyclinD1 together with pro-apoptotic Caspase-3 is limited to the frontal cortex of young transgenic APP23 mice, an area that displays with atrophy in aging mice. Expression of the cell cycle proteins CyclinD1, Cyclin-Dependent Kinase 4 (CDK4) and Proliferating Cell Nuclear Antigen (PCNA) in the brains of aging APP23 mice were limited to microglia and astrocytes, while we did not observe neuronal cell cycle protein expression in neurons. Taken together, our data supports that aberrant neuronal cell cycle events contribute early on to AD, while later cell cycle activation in the CNS associated with Aβ is linked to reactive gliosis.

Citation

Ippati S, Stevens CH, Ittner LM and Ke YD. Early Transient Neuronal CyclinD1 Expression Precedes Atrophy in the Frontal Cortex of APP23 Mice. SM J Neurol Disord Stroke. 2017; 3(2): 1015s4.