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SM Journal of Environmental Toxicology

Elja: An R Package to Perform Environment-Wide Association Studies (Ewas / Envwas) Analysis

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Received: 17-Mar-2024

Accepted: 23-Mar-2024

Published: 25-Mar-2024

Review Article | Volume 7 - Issue 1 | Article DOI :

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Marwan El Homsi¹* and Isabella Annesi-Maesano¹,²

¹Desbrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, Montpellier, France
²Division of Respiratory Medicine, Allergology, and of Thoracic Oncology, University Hospital of Montpellier, Montpellier

Corresponding Author:

Marwan El Homsi, Desbrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, Montpellier, France

Keywords

Epidemiology; Exposome; R; EnvWAS; EWAS; Package

Abstract

Environment-Wide Associations Studies (EWAS / EnvWAS) are an approach involving multiple analyses of the relationship between several exposures to a health event. This approach allows us to study the impact of an exposome on a health event. The Elja package was developed using R to perform the EnvWAS analytical approach. This package performs repeated analyses in the case of linear regression models, logistic regression models, and, more generally, generalized linear models.

The results are presented in two complementary ways. In a detailed way, with a table automatically generated at the end of the analysis allows all results to be consulted and then extracted. In a more visual way, with a Manhattan plot displaying the results in their entirety, with a significance threshold of 0.05 and the corrected threshold.

This package is compatible with Windows, Ubuntu and MacOS. It is available free of charge on GitHub (https://github.com/EHMarwan/ Elja) and the CRAN directory.

Citation

El Homsi, Annesi-Maesano I.(2024)Elja: An R Package to Perform Environment-Wide Association Studies (Ewas / Envwas) Analysis. SM J Environ Toxicol 7: 4.