Abstract
Glycogen Synthase Kinase-3β (GSK-3β) is a key component of a complex array of cellular processes. Several mechanisms are involved in controlling its activity, including phosphorylation, protein complex formation and sub cellular distribution. Aberrant GSK-3β action has been implicated in many diseases and disorders, such as cancer, heart disease, metabolic and neurological disorders. More recently, GSK-3β has been identified as a crucial regulator of the balance between pro and anti-inflammatory cytokine production. This review will highlight the immunological importance of GSK-3β and the latest discoveries that led to the identification of a new central role of GSK-3β in tumor immunity.
Citation
De Matteis S, Napolitano R and Carloni S. GSK-3β and its Unexpected Role in Immunity, Inflammation and Cancer. SM J Hematol Oncol. 2016; 1(1): 1001.