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SM Journal of Hepatitis Research and Treatment

Genetic Epidemiology of Hepatitis C Virus Infection Outcome in Upper and Lower Egypt: A Multicenter Family Based Study

[ ISSN : 2573-3672 ]

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Received: 28-May-2018

Accepted: 05-Jun-2018

Published: 12-Jun-2018

Research Article | Volume 4 - Issue 1 | Article DOI : 10.36876/smjhrt.1017

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Mahmoud El-Bendary¹*, Mustafa Neamatallah², Hatem Elalfy¹, Tarek Besheer¹, Maged El-Setouhy³, Adel El-Morsy⁴, Heba Elsayed⁵, Sally Abed¹, Mohamed Abd El-Maksoud¹, Emily Kamel⁶, Abdel-Hamid Eladl⁷ and Gamal Esmat⁸

¹Department of Tropical Medicine & Hepatology, Mansoura University, Egypt
²Department of Medical Biochemistry, Mansoura University, Egypt
³Department of Environmental and Occupational Medicine, Ain-Shams University, Egypt
?Department of Botany, Mansoura University, Egypt
?Microbiology, Mansoura University, Egypt
?Department of Public Health & Preventive Medicine, Mansoura University, Egypt
?Department of Internal Medicine, Assiut University, Egypt
?Department of Endemic Medicine & Endemic Hepatologastroenterology, Cairo University, Egypt

Corresponding Author:

Mahmoud El-Bendary, Department of Tropical Medicine & Hepatology, Mansoura University, Egypt, Tel: 00201002592205; Email; mmelbendary@gmail.com

Keywords

Chronic HCV; Spontaneous clearance; HCV genotyping; Interfamilial transmission

Abstract

Background and Aim: Egypt has high prevalence of HCV. The household contacts of HCV seropositive patients had been shown to have a high risk of HCV infection.

The aim was to determine the HCV infection outcome and genotyping among household contacts of patients in Upper and Lower Egypt.

Methods: In this multicentre study a total of 4891 individuals were recruited from Upper and Lower Egypt. The index HCV patients were 1106 cases while their household contacts were 3785 cases. All cases with HCV infection were confirmed by PCR HCV RNA technique as well as sequencing analysis of the 5′ UTR of HCV was performed and genotypes were recorded.

Results: The HCV prevalence among house hold contacts was 17.29 % and 19.17% while the spontaneous viral clearance (SVC) was 2.49% and1.55% in lower and Upper Egypt respectively.

Different genotypes and subtypes of HCV which were detected in Upper and Lower Egypt respectively: (genotype 4a ( 90.3% & 70.1%), 4m (4.8% & 11.8%) 4n (0.5% & 3.2%) 4o (0.2% & 2.9%) 4i (0.5% & 1.9%) 4v (0.8% & 1.2%) & 1a (2.9% & 8.3%) but 1g and 1b found in Lower Egypt with (0.3%) and didn’t detected in Upper Egypt. Genotype 4a was higher in Upper Egypt (90.3%) than in Lower Egypt (70.1%) and genotype 1a was higher in Lower Egypt (8.3%) than in Upper Egypt (2.9%).

Conclusion: Higher HCV prevalence in Household contacts in Upper more than lower Egypt while SVC was higher in Lower than Upper Egypt. Genotype 4 was more in Upper than Lower Egypt while genotype1a was increased in lower than Upper Egypt.

Citation

El-Bendary M, Neamatallah M, Elalfy H, Besheer T, El-Setouhy M, El-Morsy A, et al. Genetic epidemiology of Hepatitis C Virus infection outcome in Upper and lower Egypt: A multicenter Family based study. SM J Hepat Res Treat. 2018; 4(1): 1017. https://dx.doi.org/10.36876/smjhrt.1017