Keywords
Iatrogenic Kaposi sarcoma; Immunosuppression-associated Kaposi sarcoma; HHV8; Non organ transplant; Glucocorticoid; Immunosuppressant
Abstract
Kaposi sarcoma (KS) is an angioproliferative disorder affecting the skin or internal organs and is caused by human herpes virus 8 (HHV8). Four clinical variants have been recognized: classical, African endemic, AIDS-related, and KS caused by iatrogenic immunosuppression. The latter occurring more likely in patients with acquired immunodeficiency syndrome (AIDS) and those undergoing immunosuppressive treatments for organ transplant. However, few studies are related to iatrogenic KS occurring in patients other than organ transplant ones. Although it is unusual that KS occurs in patient with corticosteroids (CS), the hypercortisolism is thought to be associated with development of KS, with spontaneous regression of lesions usually occurring after discontinuation of glucocorticoid therapy, when it possible. Moreover, it can present a therapeutic dilemma, as decreasing the level of immunosuppression may lead to organ rejection in the case of organ transplant recipients, or organ damage in the case of patients with autoimmune disorders. We report a case of a 67 years old HIV-negative man treated by oral corticosteroids and methotrexate for a rheumatoid arthritis who developed an iatrogenic Kaposi’s sarcoma.
Citation
Senhaji G, Elloudi S, Gouzi I, Hammas N, Kassel J, El Jouari O, et al. Iatrogenic Kaposi Sarcoma: A Case Report in a Non Organ Transplant Patient. SM J Case Rep. 2019; 5(1): 1091.