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SM Journal of Gastroenterology & Hepatology

Impact of Clinicopathological Parameters in Chemo-Induced Adverse Drug Reaction in Treatment Strategy of Colorectal Cancer: A Hospital Based Prospective Study from Eastern India

[ ISSN : 3067-977X ]

Abstract
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Received: 06-Dec-2018

Accepted: 27-Dec-2018

Published: 31-Dec-2018

Research Article | Volume 4 - Issue 1 | Article DOI :

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Rini Roy¹ and Koyel Banerjee²*

¹Department of Molecular Biology, Netaji Subhas Chandra Bose Cancer Research Institute, India
²Department of Molecular Biology, Saroj Gupta Cancer Centre & Research Institute, India

Corresponding Author:

Koyel Banerjee, Department of Molecular Biology, Saroj Gupta Cancer Centre & Research Institute, Mahatma Gandhi Road, Thakurpukur, Kolkata, West Bengal 700063, India, Email: koyelbanerjee123@gmail.com

Keywords

Adverse Drug Reactions, clinicopathological, Causality assessment, pharmacovigilance

Abstract

Adverse Drug Reactions (ADRs) are a prime cause and a major concern especially for chemotherapy receiving patients due to their suppressed immunity to combat other subsidiary malfunctions of the body. The findings of the study include accumulation of ADRs induced by chemotherapy in colorectal cancer patients ranging between 19 to above 70 years. One hundred eighty CRC patients were included in this study. Mild to moderate ADRs were observed in all age groups with the maximum being observed in the elderly. Mild reactions were observed in 35.3% males and 37.1% females while 16.8% males and 10.8% females showed moderate reactions. Higher tumor stage and grade (p<0.05) play a crucial role in ADR. Among CRC patients most commonly found ADRs were Nausea and vomiting (16.17%) followed by anorexia (14.97%), blurred vision (13.77%) etc. Results provide an insight that DNA modifying agents and topoisomerase inhibitors have an impact on mortality rate and moderate ADR (p<0.01). Both WHO causality assessment scale and Naranjo’s algorithm revealed similar grade in ADR, except for nausea & vomiting and stool incontinence due to non-specific reaction. This study helps to correlate the mutual association of clinicopathological parameters and chemo-induced ADR and also emphasized on the need of pharmacovigilance to increase the quality life of cancer patients.

Citation

Roy R and Banerjee K. Impact of Clinicopathological Parameters in ChemoInduced Adverse Drug Reaction in Treatment Strategy of Colorectal Cancer: A Hospital Based Prospective Study from Eastern India. J Gastroenterol. 2018; 4(1): 1013s.