Keywords
Adipose Tissue; Immune System; Adipokines; EPA/DHA; Physical Exercise
Abstract
Obesity is a complex disease of multifaceted etiology, with its own pathophysiology, comorbidities, and inflammatory profile. Accepting obesity as an inflammatory process is a key process to its treatment. Currently, the adipose tissue is a major focus of research in obesity due to an evolution in the understanding of the biological function of this tissue over the last decade. It is known that adipose tissue secretes multiple bioactive peptides, termed adipokines (proteins synthesized and secreted by adipose tissue) with specific actions towards inflammation. Also, many studies have shown an anti-inflammatory role for both Omega-3 supplementation and moderate aerobic exercise. Thus, the objective of this review is to approach the relationship between obesity and inflammatory adipokines, and discuss the role of Omega-3 and aerobic exercise in the treatment of this pathology. In this narrative review data collection has been performed through research articles published in the last five years through sites like PubMed and SCIELO, including some classic articles. It has been found that the Polyunsaturated Fatty Acids (PUFAs) supplementation may be an alternative, however its use targeting the decrease in inflammation caused by obesity has little scientific evidence; nevetheless, the role of aerobic exercise as an important concomitant intervention practice is well established, due to its implications both in the hypothalamic and endocrine anti-inflammatory process.
Citation
Rocha D, Lancha AH and Campos-Ferraz PL.Inflammatory Process in Obesity and the Effects of Omega-3 Supplementation and Aerobic Exercise as Adjuvant Treatment. SM J Nutr Metab. 2015; 1(1): 1004.