Keywords
Pleural effusion; Exudative; Lymphocyte
Abstract
Background: Pleural effusion refers to accumulation of any fluid in the in the pleural space. Lymphocytic exudative pleural effusion (LEPE) is considered as one of the medical problems. A wide range of causes can produce (LEPE).This study aimed to the evaluation of causes of the pleural effusion in patients with lymphocyte- predominant exudative pleural effusion.
Methods: In this descriptive cross-sectional study, medical records of all patients admitted to the Razi and Aria Hospitals in the years 2015 to 2016 due to (LEPE). The information was derived using a form of information prepared according to the contents of the medical records, including the variables of age, gender, diagnosed cause, percentage of clinical symptom lymphocyte and diagnostic method. Patients were exposed to lymphocyte under open biopsy or thoracotomy to determine the cause of pleural effusion. In addition, the analysis of effusion and the used imaging method were examined.
Results: In this research, 119 patients with pleural effusion with lymphocyte preference were examined. Out of them, 71 cases (59.7%) were male and 48 cases (40.3%) were female. In terms of diagnostic and sampling method, 81 cases (68.1%) underwent VATS and 38 cases (31.9%) underwent thoracotomy. In terms of cause of the disease, 40 (33.6%) had lymphocytic pleuritis, 15 cases (12.6%) had lung cancer, 52 cases (43.7%) had TB, 5 cases had cancer metastases to other parts of the body and 7 cases (5.9%) had lymphocytic granulomatosis. The clinical symptom of shortness of breath had the highest frequency (52.9%). The mean age of subjects was 53.5 years and mean lymphocyte in the subjects was 81.8%. After analyzing the data and using one way Kruskal-Wallis, a significant difference was found between the mean age of subjects and different lymphocytic pleural effusion diagnoses (P = 0.0001).
Conclusion: The age factor as a determinant and predictive indicator can be helpful in diagnosis of the disease, so that at the ages lower than 40-45 years, infectious and inflammatory factors, and in the ages above 55-60 years, malignant and metastatic factors can be considered as pleural effusion factor.
Citation
Aghajanzadeh M, Mosaffaei O, Foumani AA, Tangestaninejad A, Jafarinezhad A, et al. (2019) Investigating on the Causes of Pleural Effu sion in Patients with Exudative Pleural Effusion with Lymphocyte Dominant. JSM Clin Cytol Pathol 4: 4.