Abstract
The probiotic strain Lactobacillus casei strain Shirota (LcS), has been consumed in the form of beverages in many countries. This paper studies the gut microbiota regulation effect of the beverage, instead of the strain itself. The evaluation is conducted using beverage with 108 cfu mL-1 LcS and 0.2 g mL-1 sugar on high-fat-diet hamster model. High-through put sequencing of gut microbiota showed that some of the non-dominant populations were regulated positively by LcS beverage gavage, against the changes induced by high-fat diet, such as Erysipelotrichales, Lactobacillales and Burkholderiales at Class level, Erysipelotrichaceae, Lactobacillaceae and Rikenellaceae at Family level, Coprococcus, Allobaculum, Lactobacillus and Akkermansia at Genus level, and Akkermansia muciniphila and Lactobacillus reuteri at species level. There was no significant difference in core microbiome, dominant populations or α-diversity between control and treated groups, In conclusion, the LcS beverage can regulate gut microbiota composition in high-fat diet hamster model by changing non-dominant populations.
Citation
Gao J, Gong L, Sun J, Huang J and Huo J. Lactobacillus casei Strain Shirota Supplied as Beverage Regulates Gut Microbiota in High-Fat Diet Fed Hamster. SM J Food Nutri Disord. 2017; 3(1): 1016.