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SM Journal of Sarcoma Research

Malignancy in Giant Cell Tumor of Bone: Benign Metastatic, Borderline, or Malignant? A Case Report of a Challenging Diagnosis, and Review of Literature

[ ISSN : 3068-0700 ]

Abstract
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Received: 04-Jan-2021

Accepted: 23-Jan-2021

Published: 25-Jan-2021

Case Report | Volume 5 - Issue 1 | Article DOI :

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Georgette Nader*, Hana Soueidan, Richard Danieli, Samuel Malek, Savanna Craib, Karina Leyva, Daniel Quinn and Mohamed Aziz 

Department of Pathology and Immunology- American University of the Caribbean, School of Medicine, USA

Corresponding Author:

Georgette Nader, Department of Pathology, American University of the Caribbean School of Medicine 1 University Drive at Jordan Road Cupecoy, St. Maarten, Tel: (646) 575- 6624; Email: georgettenader@students.aucmed.edu

Keywords

Giant, Malignant, Borderline, Atypia, metastasectomy

Abstract

Giant cell tumors of the bone (GCTB), while often benign, are regarded as locally aggressive and highly unpredictable with the capability to recur, metastasize, and even undergo sarcomatous transformation into a malignant variant. There have been inconsistent views regarding histomorphology, radiography and local occurrence of GCTB, and metastatic malignant GCTB. Herein, we describe the histological features of a case of GCTB with such atypical foci in which the initial diagnosis of malignancy was amended to a benign metastatic giant cell tumor. Whether the creation of a “borderline” or “atypical” GCTB category is necessary is yet to be determined.

Citation

Nader G, Soueidan H, Danieli R, Malek S, Craib S, et al. (2021) Malignancy in Giant Cell Tumor of Bone: Benign Metastatic, Borderline, or Malignant? A Case Report of a Challenging Diagnosis, and Review of Literature. SM J Sarcoma Res 5: 3.