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SM Journal of Gynecology and Obstetrics

Metabolic Disorders during Pregnancy Following Maternal Exposure to Ambient Nanoparticles

[ ISSN : 2573-6744 ]

Abstract
Details

Received: 25-Nov-2023

Accepted: 25-Dec-2023

Published: 30-Dec-2023

Research Article | Volume 9 - Issue 1 | Article DOI :

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Mojtaba Ehsanifar¹, Reihane Rajati², Marzieh Faghani Aghoozi³, and Akram Gholami⁴*

 

¹ Department of Environmental Health Engineering, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran
² Department of Midwifery, Islamic Azad University, Mashhad Branch, Mashhad, Iran
³ Department of Midwifery, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran
? Department of Nursing, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran

Corresponding Author:

Mojtaba Ehsanifar, Department of Environmental Health Engineering, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran

Keywords

Metabolomics; Placental Nutrient Transportation; Endocrine Disruption; Ambient Fine Particles; Maternal Exposure

Abstract

Animal and epidemiological studies have indicated that maternal exposure to particulate matter is related to adverse pregnancy outcomes including low birth weight in the offspring. Ambient nanoparticle or particulate matter, including PM2.5 (fine particles, PM < 2.5 μm) and PM 0.1 (very fine particles, PM < 0.1 μm), ozone and transition metals, are potent oxidants capable of generating reactive oxygen species. Redox sensitive pathways may be triggered by oxidative stress and cause various biological processes, such as inflammation and other adverse outcomes. In this mini-review, we investigated the association between ambient nanoparticle exposure and metabolic disorders in maternal serum and placenta. Findings indicated that PM2.5 exposure affected the nutrient transport capacity of the placenta by altering the ratio of some vital metabolites in the placenta to the maternal serum. These results by increasing our understanding of the ambient PM2.5 toxic effects, emphasize the importance of protecting women from exposure to PM2.5 .

Citation

Ehsanifar M, Rajati R, Aghoozi MF, Gholami A (2023) Meta bolic Disorders during Pregnancy Following Maternal Exposure to Ambient Nanoparticles. SM J Gynecol Obstet 9: 5.