Keywords
Chordoma, Sacral, Spinal, physaliphorous cells, Conventional, Metastasis
Abstract
Chordomas are rare, malignant bone tumors with a typically unfavorable prognosis that develop slowly and aggressively along the skull base and axial skeleton from remnants of the primitive notochord. Grossly, chordomas classically present as lobular nodules with thick fibrous tissue; histologically, those fibrous tissues can be seen separating chords of tumor cells in a myxoid stroma. Its characteristic local aggressiveness and indolent growth makes timely detection difficult and local recurrence likely, especially since surgical resection and radiation are the only affective treatment options. Local recurrence currently serves as a significant predictor of metastatic progression which most commonly involves the lungs, liver, bone, and lymph nodes. We report a case of metastatic chordoma to the lung, and discuss the diagnostic features, differential diagnosis, molecular changes, treatment, and prognosis.
Citation
Neal B, Nathan S, Hebert A, Davis C, Simelda J, et al. (2022) Metastatic Chordoma to the lung. Case Report of a Rare Tumor and Brief Review of the Literature. J Surg Oncol Clin Res 4: 5.