Submit Article
Back to Journal

SM Journal of Stem Cell Research

The Existence and Signaling of Cancer Stem Cells in Non-Small Cell Lung Cancer

[ ISSN : 3068-0719 ]

Abstract
Details

Received: 14-Apr-2016

Accepted: 10-May-2016

Published: 12-May-2016

Review Article | Volume 2 - Issue 1 | Article DOI :

Download PDF

Ma Lin1* 

1The State Key Lab of Pharmaceutical Biotechnology, College of life Sciences, Nanjing University, Nanjing, China

Corresponding Author:

Ma Lin, The State Key Lab of Pharmaceutical Biotechnology, College of life Sciences, Nanjing University, Nanjing, China, Email: xeno.ma@163. com

Abstract

Non-small lung cancer (NSCLC) is one of the most aggressive malignant tumor diseases accounting for a large group of all lung cancer cases, and patients with NSCLC have very poor prognosis with short survival time and high reccurence rates after therapy. This phenomenon could be illustrated by the existence of cancer stem cells (CSCs) which is well supported by a large number of previous studies. Herein we generalize signaling and mechanisms (mainly including WNT, notch and hedgehog pathways) involved in cancer stemness in NSCLC according to recently-published data with briefly-described CSC identification and evaluation methods. All of above will help lead to new advances in therapy against CSCs and improvements in prognosis of NSCLC patients.

Citation

Lin M. The Existence and Signaling of Cancer Stem Cells in Non-Small Cell Lung Cancer. Stem Cell Res. 2016; 2(1): 1005.