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SM Journal of Environmental Toxicology

Therapeutic Potential of Sub- Acute MgO Nanoparticle Exposure Against Lungs Injury Associated Systemic Complications in Rat Model

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Received: 02-May-2024

Accepted: 15-May-2024

Published: 07-May-2024

Research Article | Volume 7 - Issue 1 | Article DOI :

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Muhammad Aslam¹*, Arslan Shaukat², Ecem Metin³ and Naheed Khan⁴

¹Laboratory of Neurosciences, Graduate School of Health Sciences, KOC University, Turkey
²Laboratory of physiology, Government College University Faisalabad, Pakistan
³Research Center for Translational Medicine (KUTTAM), Koç University, Turkey
?Laboratory of Reproductive Physiology, Department of Zoology, Quaid-i-Azam University, Pakistan

Corresponding Author:

Muhammad Aslam, Laboratory of Neurosciences, Graduate School of Health Sciences, KOC University, Istanbul, 34450, Turkey

Keywords

MgO nanoparticle; Body weight; Cigarette smoke; Histopathological; Inflammation

Abstract

Acute lung injury is characterized by acute inflammation and disruption of the lung endothelial and epithelial barriers. Acute Respiratory Distress Syndrome or ARDS clinically characterized by bilateral or diffuse radiographic infiltrates, hypoxemia, decreased lung compliance, and increased ventilatory dead space. The histological manifestation of ARDS is diffuse alveolar damage as defined by epithelial injury, hyaline membrane formation and alveolar flooding with proteinaceous fluid, increase alveolar surface area and frequently neutrophilic inflammation. This study was designed to investigate the ameliorative effect of MgO Nanoparticle, on body weight, BALF, antioxidant activity, liver, lipid profile, complete blood count and lungs in cage cigarette smoke acute lung injury rat model. Thirty albino healthy male rats were randomly divided into five experimental groups, negative control group (NCG), positive control group (PCG), standard control group (SCG), low dose treatment group (LDTG-MgO 150), high dose treatment group (HDTG-MgO 300). Results revealed that MgO nanoparticles exhibited dose dependent increase in body weight, reduced inflammatory cell infiltration in alveoli, normalized antioxidant capacity, attenuate hepatic damage, reduced serum total cholesterol, triglycerides, HDL-c LDL-c, increased peripheral blood WBCs, RBCs, Hb and platelets, attenuate the lungs histopathological alterations, progressive enlarged alveolar space, bronchial constriction, dilation and thinning of pulmonary vessel. Intra-alveolar multinucleated macrophages accumulation, apoptosis and deterioration of alveolar walls in” cage cigarette smoke acute lung injury rat model. Conclusively this formulation of selected nanoparticles at high dose exhibited dose dependent potential ameliorative effect on acute lung injury and can be valuable therapeutic intervention.

Citation

Aslam M, Shaukat A, Metin E, Khan N (2024) Therapeutic Potential of Sub- Acute MgO Nanoparticle Exposure Against Lungs Injury Associated Systemic Complications in Rat Model. SM J Environ Toxicol 7: 11.