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SM Journal of Pharmacology and Therapeutics

Understanding the Bioavailability of Ca2+ in Biological Fluids in the Presence of Risedronic Acid

[ ISSN : 2574-2396 ]

Abstract
Details

Received: 07-Nov-2016

Accepted: 19-Dec-2016

Published: 02-Jan-2017

Research Article | Volume 3 - Issue 1 | Article DOI :

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Bretti C¹, Cataldo S², Cigala RM¹, Lando G¹, Pettignano A² and Sammartano S¹

¹ Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy
² Department of Physics and Chemistry, University of Palermo, Italy

Corresponding Author:

Gabriele Lando, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres, 31, I - 98166 Messina (Vill. S. Agata), Italy, Tel: +39 090 676 5748; Email: glando@unime.it

Keywords

Ca2+; Bioavailability; Risedronic acid; Calorimetry; Potentiometry; Modeling; Case studies (Urine, Saliva, Human blood plasma)

Abstract

In this work, potentiometric and calorimetric measurements were carried out in aqueous NaCl solutions at different temperatures (283.15 ≤ T / K ≤ 318.15) and ionic strengths (0 < I / mol dm-3 ≤ 3.0), to study the interaction of Ca2+ and Risedronic Acid (RA), a drug used for the treatment of various bone disorders and belonging to the class of Biphosphonates (BP). The experimentally determined speciation model of the Ca2+/Risedronate system consists of four species, namely the neutral CaH2 L and Ca2 L and the negatively charged CaHL- and CaL2-. Calorimetric experiments allowed us to determine the thermodynamic properties of the various species, and to calculate formation constants at temperature different than 298.15 K. All the species (except the Ca2 L) resulted exothermic and the main contribution to the stability is entropic in nature. The aim of the paper is to predict the influence of the risedronate on the speciation of Ca2+ in various simulated biological fluids as human blood plasma, urine and saliva.

Citation

Bretti C, Cataldo S, Cigala RM, Lando G, Pettignano A and Sammartano S. Understanding the Bioavailability of Ca2+ in Biological Fluids in the Presence of Risedronic Acid. SM J Pharmac Ther. 2017; 3(1): 1014s.