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SM Vaccines and Vaccination Journal

Induction of Autoimmune Diseases Following Vaccinations: A Review

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Received: 17-Nov-2015

Accepted: 17-Dec-2015

Published: 18-Dec-2015

Review Article | Volume 1 - Issue 3 | Article DOI :

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Daniil Hammoudi7 , Adekunle O Sanyaolu1,4*,Verner N Orish2 , Onyekachi S Onyeabor3 , Imene Benayache5,7, Danny A-S Hammoudi6,7, Nnaemeka C Iriemenam4 , Katherine Ellard1 and Kyle Ridge1

1Department of Medical Microbiology & Immunology, Saint James School of Medicine, Anguilla

2Department of Internal Medicine, Effia-Nkwanta Regional Hospital Sekondi-Takoradi, Sekondi, Ghana

3Department of Community Health and Preventive Medicine, The Satcher Health Leadership Institute, Morehouse School of Medicine, USA

4Department of Medical Microbiology and Parasitology, College of Medicine of the University of       Lagos,Nigeria

5Department of Cardiology, Johns Hopkins University, USA

6Dickinson College, Biochemistry Department, USA

7Sinoe Medical Association, Baltimore Maryland, USA

Corresponding Author:

Adekunle O Sanyaolu, Department of

Medical Microbiology & Immunology,

Saint James School of Medicine,

Anguilla,

Keywords

Vaccinations; Autoimmune diseases; Molecular mimicry; Bystander activation; Hepatitis B vaccine; Influenza vaccine; MMR vaccine; Smallpox vaccine; HPV vaccine

Abstract

Autoimmune reactions to vaccinations have been reported since vaccines were introduced into modern medical technology. Here, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanisms by which vaccines can cause autoimmune reactions. Idiopathic Thrombocytopenia Purpura, Myopericarditis, Primary Ovarian Failure, Systemic Lupus Erythematosus (SLE) and Acute Disseminated Encephalomyelitis (ADEM) are all autoimmune conditions with reported links to vaccinations. Genetic predisposition was a definite risk factor for people experiencing autoimmune conditions following immunization; thus understanding the genome of patients is vital for both the development of future generations of vaccines and personalized medicine. Further study is encouraged into the direct associations between vaccines and autoimmune conditions, and the biological mechanisms behind them.

Citation

Hammoudi D, Sanyaolu AO,Orish VN, Onyeabor OS, Benayache I, Hammoudi DA-S et al., Induction of Autoimmune Diseases Following Vaccinations: A Review. SM Vaccine Vaccin. 2015; 1(3): 1011.