Abstract
The oncogenesis of Prostate Cancer (PCa) is a process involving epithelial cells of the gland and their interaction with the stroma. Reactive stroma formation has been shown to be critical in the progression of many cancers. In PCa, the reactive stroma is unique when compared with other cancer types and characterized by replacing the normal well differentiated smooth muscle cells with fibroblasts and myofibroblasts. The Masson’s trichrome stain and immunohistochemistry (IHC) / immunofluorescence studies characterized these changes and a grading system of reactive stroma has been developed. In this review, the changes of the molecular and morphometric features of the reactive stroma during the progress of PCa, and their use in clinical implications in the diagnosis, prognosis prediction and potential treatment of PCa are discussed.
Citation
Zhu G and Veltri RW. Stroma Features in Prostate Cancer Diagnosis and Prognosis. SM J Biol. 2015; 1(1): 1004.