Anaplastic thyroid carcinoma (ATC), is a rare, highly aggressive, and undifferentiated thyroid malignancy. Given the delayed diagnosis, ATC contributes to more than 30% of thyroid cancer associated deaths each year. Most ATC lesions are found within the neck region following metastasis to distant organs and lymph nodes. Diagnosis of anaplastic thyroid carcinoma is particularly challenging given the late presentation of compressive symptoms, histological variety, and rarity of the neoplasm. Early detection can be done with screening methods for high-risk patients with prior history of thyroid neoplasms. Even with a multimodal approach to therapy, ATC diagnosis yields a poor prognosis with less than six months of survival.