Berberine is a type of bioactive compound that belongs to the class of alkaloids, and is extracted from the shrubs called Berberis. This study was performed to analyze the effect of the Trivedi Effect®-Consciousness Energy Healing Treatment on berberine chloride in terms of altering its physicochemical properties by using modern analytical techniques. The study was done by dividing the sample in control and a treated part. The control sample did not give treatment, while the treated part received the Trivedi Effect® remotely by the Biofield Energy Healer, Dahryn Trivedi. The PXRD study indicated the significant alterations in the peak intensities of the treated berberine in the range of -7.30% to 309.30%; while the crystallite sizes were altered in the range from -73.02% to 72.04%, compared to the control sample. The treated berberine also showed alteration in the average crystallite size that was significantly decreased by 11.86% as compared to the control sample. The particle sizes of the treated berberine were observed to reduce by 6.14% (d10 ), 11.22% (d50 ), 15.63% (d90 ), and 12.40% {D (4,3)}, which thereby attributed to 5.26% increase in the specific surface area as compared to the control sample. The total weight loss of the treated berberine showed a significant reduction by23.71% and 45.79% increase in the residue weight than the control sample. The treated berberine showed alterations in the melting temperatures corresponding to 1st, 2nd, 3rd, 4th, 5th, and 6th peak by -3.78%, -2.99%, 1.14%, 0.50%, -0.15%, and -0.53%, respectively; while the latent heat was altered by -66.59%, 20.04%, 26.32%, -12.31%, -40.34%, and 44.22%, respectively, compared to the control sample. The analysis indicated the significant impact of the Trivedi Effect® on berberine chloride that might show better solubility, bioavailability, and thermal stability as compared to the control berberine. Thus, the Trivedi Effect® could be helpful in designing the novel formulations of berberine chloride to fight against various diseases and disorders with improved efficacy and performance.

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