Physicians, prolonging the life of the carriers of harmful mutations, reduce the reliability of the existence of supraorganismal systems of populations. Cancer – this is probably a compensatory response of populations on these activities of physicians. In some wild animals, under the influence of anthropogenic deterioration of the environment, evolution has taken the path of reducing life expectancy [1]. This accelerated the change of generations and facilitated the restructuring of the genetic make-up of populations in accordance with a changing environment.

Urinary incontinence and falls are prevalent health conditions in the older population. Although there are many recommended functional falls assessments available, there is lacking evidence on the use of UI for falls screenings. This paper includes a mini review on urinary incontinence and falls assessments in the older population, and a preliminary case series investigating the relationship between UI and functional falls assessments. Analysis of sex and UI suggests that sex and urinary incontinence are not independent over the age of 65 (p = 0.1667). Urinary incontinence and fall risk per functional measure were strongly rank-correlated for the under 65 population (ρ = 1, p = 0.1333), as were UI and TUG score (ρ = 0.8281, p = 0.1333), and total number of fall risk factors and fall risk per functional measure (ρ = 0.8402, p = 0.1333). In the participants under 65 years old, those with UI have a tendency to demonstrate higher TUG scores and a higher likelihood of being identified as a potential faller; the under 65 cohort also demonstrates a higher number of risk factors when testing positively on the included functional fall measures.

We present a short review of human skin aging with a complete list of our previous publications as well as on fibroblasts and their aging process. Age-dependent skin loss was measured on biopsy samples from a relatively large number of Caucasian Europeans, males and females, showing a loss with age of about 7% of the “original” (0 age) skin thickness every 10 years. The age-dependent loss of two major constituents of the skin extracellular matrix, collagen and elastin and their age-dependent modifications are described in some detail. We insisted on the age-dependent loss of hyaluronan, the most important reason of loss of hydration and wrinkling.

Purpose: Complex analysis of the effect of Cerebrolysin (intravenous infusion of 10 ml for 10 days) on the hemodynamic and bioelectrical activity of the brain.

Methods: Total 25 elderly patients who developed post-atherothrombotic ischemic stroke (nearly one year after acute period) were included into study. Their electroencephalogram was recorded on the 16-channel electroencephalograph 110 Neurofax EEG (NichonKogden). An ultrasonic duplex scanning of head and neck vessels was done on the device APPLIO 600 (Toshiba).

Results and Discussion: Due to Cerebrolysin treatment we observed the statistical increase of Linear Systolic Blood Flow (LSBF) rate in some brain vessels Besides, we have observed positive reorganization of bioelectric brain activity, decrease in delta and theta power in separate areas of both hemispheres and alpha rhythm power in all areas of the right/left hemispheres against a background of increased alpha rhythm frequency. Cerebrolysin harmonized inter-systemic interrelations between the power of separate rhythms of brain bioelectric activity and cerebral hemodynamic (LSBF).

Conclusion: Thus Cerebrolysin effects on the brain bioelectric activity are more harmonious in the patients with left- versus right-sided stroke localization that apparently determines the hemispheric peculiarities of recovery processes

Urethral Bulking Agents (UBAs) are injected locally as a minimally invasive procedure for Stress Urinary Incontinence (SUI) and are beneficial for properly selected patients. Many different materials have been developed and are available, although none so far meet all the requirements of an ideal agent. The first UBA was cross-linked bovine collagen (Contigen®), followed by autologous fat injections, solid silicone particles (Macroplastique®), microspheres covered with pyrolytic carbon (Durasphere®), calcium hydroxyapatite (Coaptite®), polyacrylamide hydrogel (Bulkamid®), and dextran/HA copolymer (Zuidex®). The latest product development is PDMS-U, a silicone gel bulking agent that polymerizes in situ (Urolastic®).

The ideal urinary bulking agent could consist of permanent microspheres, which immediately elicit a modest foreign body reaction along with the production of fibro-vascular tissue, which encapsulate every single microsphere individually and prevent their migration from the injection site. Polymethylmethacrylate microspheres have a successful history as dermal fillers used world-wide and can be safely injected submucosally at the urinary sphincter under direct vision, rather than peri-urethrally into the muscle like most of the present agents.

Overall, short-term clinical results with most of the currently used urinary bulking agents are encouraging; however, longer follow-up results are often disappointing and retreatment is required. Proper patient selection and a safe, biocompatible and non-migrating bulking agent that elicits permanent fibro-vascular tissue formation at the injection site are paramount to successful treatment of stress urinary incontinence.