We introduce a novel catoptric objective based high sensitive Fourier Domain Optical Coherence Tomography (FD-OCT) system for enhanced structural and functional imaging of cochlear microstructures. Unlike the conventional refractive type microscopic objective, catoptric objectives are well-known for their chromatic aberrations free operation and high light gathering efficiency for a broad range of wavelengths. In this study, we present the feasibility of a commercially available catoptric type objective to obtain high-sensitivity structural and functional imaging of cochlear microstructures of an excised guinea pig through intact temporal bone.

T he ability to encapsulate chemotherapeutic drugs in tiny nanoparticles measuring anywhere between 1-100 nm in size is an emerging space with leading pharmaceutical companies spending billions of dollars on research to explore their potential.

Recent reports by BBC News [1], New Scientist [2], Popular Mechanics Magazine [3] and Discover Magazine [4] on the invention of a new Ultra Short Pulsed (USP) laser technology by a U.S. group led by Kong-Thon Tsen of Arizona State University and Shaw-Wei D.

The Fluid-Structure Interaction (FSI) computational method is in arising in the field of biomechanics. One of the most applicable problems in this area is the interaction of solid and fluid in the blood vessel. It may also have implication to understand the complexity of arterial diseases to figure out the interaction of fluid and arterial wall. So far many studies have been carried out to compute the stress and deformations of the blood in a cerebral aneurysm artery. Dynamic behavior of the blood in an artery would pave the way to understand the growth, rupture, and curing of the cerebral aneurysm. Therefore, in this study the dynamic behavior of the blood flow and its interaction with the basilar arterial wall was simulated using FSI approach. Thereafter, the von Mises stress, shear stress as well as deformations of both the arterial wall and blood were computed and compared to that of the healthy one. The mechanical behavior of the arterial wall was considered to be elastic, isotropic, homogenous, and incompressible, and the behavior of the blood flow was assumed to be laminar, Newtonian, and incompressible. The results of the present study may have implications for understanding the stresses and deformations of the blood flow in a healthy and basilar aneurysm artery.