Wound infection leading to the uneasy wound management is an outrageous problem which needs to be solved seriously. This work aims to fabricate one drug carrier system, and the loaded natural antibacterial agent can be released in a controlled and long-lasting manner, especially under the pH value of alkaline environment. The results show that the fabricated drug carrier, Poly (Ethylene Glycol) (PEG) grafted on Graphene Oxide (GO) (denoted as PEG-g-GO), can carry Berberine Chloride Hydrate (BCH) with high efficiency and then release it in a controlled way against different pH values. Furthermore, such BCH carrier can be easily coated on the cotton fabric, and finally the functional fabric may show potential to be applied as an antibacterial wound dressing to control the wound infection and thus erase the unpleasant odour.

This paper provides a description of an integrated, web-based and fully automated healthcare institution quality management system. The system includes many features and applications that provide better alignment with quality assurance strategy and best practices benchmarks. It is based on a proven design approach that supports and enhances the quality of medical and healthcare services. The different stakeholders are provided with a common framework for designing, implementing, controlling, evaluating and improving these services. The software system is customizable and scalable in the sense that additional functionality based on the needs and requirements of individual institution can be easily implemented or supported.

Background: The complex structure of the nasal cavity filters most of the nasally administered aerosols and prevents effective drug delivery to the olfactory region. Due to low medication bioavailability in this region, treatment of brain tumors with direct nose-to-brain drug delivery is still not feasible.

Objectives: The objective of this study is to experimentally evaluate the performance of a hybrid delivery method in an image-based nasal model by leveraging the advantages of both the bi-directional delivery strategy and the electric field guidance of charged particles.

Methods: A sectional hollow nasal cast model was developed from an anatomically accurate nasal airway model that allowed direct quantification of olfactory deposition and visualization of regional deposition distributions. Influences of different electric field strengths and two delivery strategies (normal and bi-directional) on the olfactory delivery were tested.

Results: Results show that olfactory deposition is very sensitive to the voltage of the electrode close to the olfactory region. For both the normal and bi-directional deliveries, electric field guidance resulted in a significant increase (3–5 times) in deposition in the olfactory region. The olfactory deposition with electric guidance was 1.6 times higher when using the bidirectional method than under normal breathing conditions.

Conclusions: Results of this study indicate that the combination of electric field guidance of charged particles and the bi-directional delivery strategy is promising to deliver significantly improved medications to the olfactory region.

Atherosclerosis is a progressive, chronic, inflammatory disease that causes the narrowing and hardening of both the medium and large sized arteries by excessive plaque formation within the artery walls. It is expected that by 2020, atherosclerosis will be the leading cause of death globally. The mechanisms of atherosclerosis are complex and multivariate, not all of which are fully understood. The use of in vitro models is vital to mechanistically predict the main triggers of the disease, disease risk level, determine suitable treatments and to ascertain the efficacy of potential treatment options. This review provides a comprehensive summary of the different studies and co-culture methods used to investigate the mechanisms of atherosclerosis in vitro.

At present, every third individual in the Western world is diagnosed with a cancer at some point in their lives. In spite of great advances in oncology in recent decades, around 50% of these individuals will die from their diseases.

The aims of this study were to evaluate the ultrasound Quality Control (QC) testing in Najran, Saudi Arabia and to derive an accurate Gestational Age (GA) formula based on the errors of QC tests.

Using Gammex RMI and CIRS phantoms for twenty four ultrasound systems in the five hospitals the results of penetration depth, distance accuracy, image uniformity, dead zone and axial resolution were reported in this study. On the other hand, a dataset of 35 pregnancies were studied to assess the accuracy of GA during the first and second-trimesters.

Most QC results in all hospitals were found to be within the baseline levels and the best performance derived formula was found a combination of Biparietal Diameter (BPD), Femur Length (FL) and distance accuracy. Periodic QC evaluation should be carried out to motivate the optimization of accurate dating of pregnancy.