SM Journal of Clinical Pathology

Archive Articles

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Individualization of Neoadjuvant Chemotherapy in Breast Cancer

The preoperative, or, as it is often called, neoadjuvant chemotherapy (NAPCT) of operable breast cancer (the breast cancer) with affected regional lymph nodes has in its time replaced preoperative radiotherapy, as it has a number of significant advantages over the latter. The most important advantage of NAPCT is its systemic action, which allows to “catch up” with probable distant micrometastases or circulating tumor cells, while preoperative radiotherapy has a local effect, and on the systemic level the tumor continues to develop. Despite of the fact that with operative breast cancer the time of NAPCT (before or after the operation) does not affect to the long-term results of treatment, the latter becames applicable even for operable breast cancer without affected regional lymph nodes.

Hojouj Mohammad IM*


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Oral Teratoma-An Unusual Presentation

An oropharyngeal teratoma (epignathus) is a rare malformation which is composed of cells from all the three germ layers. Epignathus may arise from the palate or pharynx and then protrudes out from the mouth. We intend to present a case of oropharyngeal teratoma originating from the hard palate in a newborn. The lesion was excised which on histopathological examination showed features of mature teratoma without malignant transformation. Recurrence was not observed after 12 months of follow-up.

Kafil Akhtar¹*, Saquib Alam¹, Atia Zaka ur-Rab², and Rana K Sherwani¹


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Pseudoglandular and Myxoide Adenoma of Adrenal: Case Report

Myxoidal tumors of the adrenal cortex are rare. The first case was reported in 1979. Until 2008, 20 cases were reported, of which 11 were carcinomas and 9 were adenomas. We report the case of a 40-year-old patient with no specific history who had left nephritic colic. The uroscanner revealed the presence of an adrenal mass of 5 cm long axis. An incidentaloma diagnosis was made with a left adrenalectomy decision. Histological examination showed a tumor proliferation made of tubes of variable size, bordered by cubic and cubo-cylindrical cells with eosinophilic cytoplasm and nucleus without atypies and without visible mitoses. This proliferation is surrounded by a capsule with the persistence of a thin rim around the periphery of normal adrenal parenchyma. The immunohistochemical study is in favor of an adrenocortical adenoma. In conclusion, the histological features of pseudoglandular myxoid adenoma are often clean for a primitive adrenal tumor even though they may be superficially interpreted as metastatic adenocarcinoma

Amine Kessab¹˒²*, Mohammed Allaoui¹˒², Med Reda Elochi¹˒², Abderrahmane Al Bouzidi¹˒², and Oukabli M¹˒²


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EBV-Associated Smooth Muscle Tumor Mimicking Schwannoma In AIDS Patient: A Case Report

Many tumors are associated with acquired immune deficiency syndrome (AIDS), such as Kaposi sarcoma, Burkitt’s lymphoma, nasopharyngeal carcinoma, and smooth muscle tumor. This paper describes the EpsteinBarr virus (EBV)-associated smooth muscle tumor (EBV-SMT) in patient with AIDS, clinically mimicking schwannoma. So, EBV-SMT should be included in the differential diagnosis for a mesenchymal tumor arising in any organs in AIDS patients.

Samasuk Thammachantha¹, Sirirat Khunvutthidee², and Korrapakc Wangtanaphat³


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Condition and Haematological Values of Free-Ranging Eastern Pacific Green Turtles (Chelonia Mydas) from Baja California Sur, Mexico

Background: Marine turtles face a wide range of environmental and anthropogenic factors that can cause disease and in severe cases death. Health and diseases of marine turtles are studied more frequently in different parts of the world; however, their prevention, control or treatment has been infrequently addressed. Therefore, the information generated on the health values of marine turtles becomes a useful tool to achieve the relevant conservation strategies. The objective of this study was to assess the health of free-ranging Eastern Pacific green turtles (Chelonia mydas) from the neritic foraging developmental habitats in Baja California Sur.

Methods: 29 C. mydas were evaluated with clinical exams, then, 29 blood samples were collected and hematic biometrics were performed.

Results: Turtle health panels included in this study are ranked as “good” based on clinical examination and hematologic diagnostics. Marine turtles are sentinels, ecosystem health indicators, therefore, the good health of these organisms, allows us to infer that Ojo de Liebre lagoon is a healthy ecosystem.

Conclusion: Develop site-specific blood values for wild marine turtle populations, helps to create effective management protocols and improves our ability to understand the effects of anthropogenic and environmental changes on the health of marine turtles and the coastal ecosystems that inhabit

Eduardo Reséndiz¹˒²˒³*, Helena Fernández-Sanz¹˒⁵, Dilan Ramos¹˒⁴, Valeria Lucero Silva¹, and María Mónica Lara-Uc¹˒²˒³