Metabolic syndrome is a cluster of metabolic disorders, including increased fasting glucose, blood pressures, plasma triglyceride, and reduced High-Density Lipoprotein (HDL) cholesterol concentrations and abdominal obesity.

The prevalence of type 2 diabetes mellitus is rapidly increasing worldwide. In 2010, the global prevalence was estimated at 8.3% of the adult population, a proportion that is projected to increase to 9.9% by 2030.

Glycohemoglobin (HbA1c) is the N-terminal (1-deoxyfructosyl) valineglycation product of hemoglobin Hb A0 .

Neuropathy and ischemia are the main disorders found in the ulceration underlying foot. The diabetic foot is the biggest complication of diabetes in the world. It estimates that 16 million of people in the carrying the United States of diabetes mellitus, about 15-20% will go to be hospitalized for complications of the diabetic foot. The inquiry concerning the physiopathologic alterations of the involved factors in the healing process of the carrier of diabetes mellitus and the complications generated for the vascular dysfunction still presents gaps. In this review, it was aimed to analyze the involved components in the tissue repair and its alterations in the diabetic patient. This is a descriptive study in which had analyzed articles indexed in the databases PUBMED and MEDLINE, in the period of 1930-2016. The study disclosed that some factors in the process of tissue regeneration, as the vascular endothelial growth factor and the fibroblast growth factor, could be altered to the hyperglycemic state. Moreover, the alterations of oxidative stress in special nitric oxide could influence negatively in the tissue repair.