Topical corticosteroids, being one of the most frequently prescribed classes of drugs in clinical practice today, are very often subjected to misuse. A vast majority of the patients are unaware of the untoward effects that may arise even with the right administration of these drugs. The ethical use and the regulatory challenges concerning the use of topical corticosteroids are the issues of the hour. The pediatric population is highly susceptible due to variability in body surface area, skin thickness and texture, and the resulting increased permeability predisposes them to systemic side effects like Cushing’s syndrome and adrenocortical insufficiency. Overutilization of steroids also augments the susceptibility of an individual to hospital and community acquired skin infections. With this review, we aim to bring the ever expanding trend of steroid misuse to the light by evaluating the risk vs. benefit factor. Steroid misuse is an emerging public health concern and in order to address this issue, analysis and comparison of prescribing pattern, understanding of topical administration and side effects associated with topical steroids are vital.

Cancer is an extremely deadly disease. It is undoubtedly one of the main health concerns facing our society and on of the primary targets regarding medicinal chemistry. Even though Platinum based complexes had been in primary focus on research on chemotherapy agents, the interests in this field have shifted to non platinum based agents in order to find different metal complexes with less side effects and similar or better cytotoxicity .Thus a variety of metal complexes based on GOLD are being intensivel studied as platinum replacements. There is every need to develop these gold complexes as they are isoelectronis with platinum and these could someday become the replacement for Platinmu based anticancer Drugs.

norganic chemotherapy has been considerably boosted in recent years by the discovery and exploitation of antitumor compounds based on platinum. Some Gold (III) complexes display similar chemistry and pharnmacological activity to cis-platin and its analogues are now the basis of multimillion dollars industry and bring benefit to thousands of cancer patients. Platinum based anticancer drugs induce normal tissue toxicity particularly to the kidneys and thus alternative metal compounds are presently being evaluated in clinical trials. Gold is one of the most promising metals and its compounds are regarded as promising alternatives in cancer therapy and offer many approaches to innovative Metallopharmaceuticals.

Cancer is a deadly disease with a high mortality rate and the most advanced oncology centers of the world are trying to find solutions for it. The most advanced method used for treating cancer is based on the change of metabolism in cancerous cells, namely, the rise of enzymes participating in metabolism and the supply of energy to the cell. Malic enzyme 1 regulates the redox equilibrium, cellular energy, and the synthesis of biomolecules by conversion of a TCA cycle intermediate, malic acid, into NADPH and pyruvic acid. Thus, Malic enzyme 1 seems like a capable asset in the treatment of cancer and its inhibitors can be used to hinder the growth of the cancerous cell. In the present study, we have been using Fragment-based method of drug discovery using molecular dynamic simulation and molecular docking in order to create an inhibitor for malic enzyme 1. After testing roughly ninety thousand pieces of interaction with the binding site of NAD (P) with regard to the type of interactions, binding energy, and the compound orientation on the site, finally, combination 1f was selected as the best inhibitor.