Single Incision Thoracoscopic Surgery (SITS) aims to provide effective surgical treatment for thoracic disease within the thoracic cavity; it strives to minimize access-related morbidity while maximizing the cosmetic advantage.

An isolated unilateral pleural effusion as the only presentation of Ovarian Hyperstimulation Syndrome (OHSS) is very rare. Here, we report an unusual case with an isolated unilateral pleural effusion without ascites after In-Vitro Fertilization (IVF) by ovarian stimulation with a review of the literature.