Isocitrate dehydrogenases IDH1 and IDH2 are closely-related metabolic enzymes which catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) by oxidative decarboxylation and simultaneously generate NADPH in cells

An 59 year-old patient complaining of progressive worsening of lower back pain with new bilateral leg weakness limiting mobility. Physical examination showed paraesthesia localising to L5/ S1 dermatomes bilaterally. Patient has no previous injury or co-morbidities.