Introduction: Human papilloma virus (HPV) is a public health concern because of its association with cervical cancer. Despite the evidence about HPV vaccination benefits, debate persists about the rate of receiving HPV vaccination.

Objective: The main objective of this study is to examine the uptake rate of HPV vaccination among White-American females.

Design and Method: This study analyzed data from the 2015 and 2016 National Health Interview Survey (NHIS), a cross sectional study of non-institutionalized population in the United States. Females aged 18-85 years were included in the survey.

Result: The White-American females odds are (OR=3.84; 95% CI 2.74-5.39) three times higher than males.

Conclusion: Our results highlight the uptake rate of HPV vaccination in preventing cervical cancer among White-American population.