Introduction:
Multiple exostosis disease is rare. We report three familials forms of this disease a found by a systematic screening of three cases.

Patients and Methods:
Study carried out in the Rheumatology Department of the Aristide Le Dantec University Hospital in Dakar, between December 2015 and June 2018. We have collected patients from families with multiple exostosis disease.

Results:
The family study included a total of 108 members, 15 of whom (13 male and 2 female) had multiple exostosis disease. The family prevalence was 13.88%. The average age was 6 years at the apparent onset of the disease and 21 years at diagnosis. The inbreeding rate was 55%. The average time to diagnosis was 15 years. The number of osteochondromas recorded in a patient varied between 4 and 17. Exostosis was localized to the limbs in 87.30% of cases and to the axial skeleton in 12.70% of cases. Standard radiographs showed sessile form in 14 patients and pedicularformin 2 patients. The evolution after the end of growth was marked by a recovery of activity. Osteo-articular complications and vascular compressions were noted in 5 and 3 cases respectively. No cases of malignant degeneration have been reported. Surgical treatment was performed in 3 cases.

Conclusion:
Family character of the multiple exostosis disease in our patients is in favor of the implication of genetic factors in the determinism of the disease. We encourage systemic screening of the family for all cases of multiple exostosis disease.

Plantar fibromatosis of the foot (i.e. Ledderhose’s disease) is a rare benign but local aggressive disease of the plantar aponeurosis (i.e. fascia) with unknown etiology. Histopathological findings in plantar fibromatosis reveal similar findings to those in palmar fibromatosis (i.e. Dupuytren’s disease), and genetic factors (i.e. familial history) for its appearance seems to be of relevance. Treatment options include various non-surgical and surgical procedures; however, progression of disease after non-surgical treatment and recurrence after surgery is a concern. But in trend, total plantar fasciectomy seems to be superior compared to all other procedures. The aim of this short review article is to give practicable interdisciplinary insights on a surgeon’s perspective for all clinicians who are confronted with this rare disease including various differential diagnoses related to chronic plantar foot pain, and possible complications after its treatment.

The present research was performed to monitor the anti-rheumatoid action of Consciousness Energy Healing based DMEM medium using synovial sarcoma cell line, SW982. The study included the evaluation of bone health potential using inflammatory parameter, IL-8. The test item (DMEM medium) was divided into three parts, first part received a one-time Consciousness Energy Healing Treatment by a renowned Biofield Energy Healer, Mahendra Kumar Trivedi and was labeled as the one-time Biofield Energy Treated (BT-I) DMEM, while second part received the two-times the Biofield Energy Treatment and is denoted as BT-II DMEM. The third part did not receive any treatment and defined as the untreated DMEM group. Cell viability assay using MTT method showed that the cell viability of SW982 cells was 113.8% and 88.3% in the BT-I and BT-II groups, respectively. The BT-I group demonstrated significant (p≤0.001) inhibition of IL-8 by 27.74%, while BT-II group also showed a significant (p≤0.001) inhibition of IL-8 by 45.66% as compared to the untreated DMEM group. In conclusion, the data suggested that the Consciousness Energy Healing Treatment significantly inhibited the pro-inflammatory cytokine (IL-8) that showed anti-rheumatic action and can also be used in other bone and inflammatory disorders such as osteoporosis, Paget’s disease of bone, rickets, deformed bones, osteomalacia, osteoma, stress, aging, bone loss, and fractures along with autoimmune disorders and overall quality of life.