Programmatic Management of Drug Resistant TB in India faces stiff contemporary challenges as evinced from four recent publications highlighting high treatment failure and death rates. The challenges and suggestions for their remediation have been tackled herein, through the themes of amplified drug resistance findings, the strategy to take drug resistant TB (DR – TB) treatment to peripheral health facilities; caring for the wider needs of DR – TB patients and understanding patient behavior. The strengthening of laboratory infrastructure and competencies is strongly recommended. Technology, both biomedical and epidemiological, is required to design empirical and locally relevant backbone drug regimens. Skills for ground level management of DR – TB, including adverse drug reactions (ADR), need to be rapidly developed and deployed. Programmatic management needs to focus on “care” as much as on “cure”.

The immune system is a defense system, both children, and adult have the same reaction toward pathogen, uses multiple defense mechanisms evolved to recognize and neutralize pathogens also have the ability to distinguish self from non-self cells, but in case of Varicella-zoster virus (VZV) that cause chicken pox, the immune system reacts differently in young healthy adult usually have an aggressive reaction serious complications can lead to death, compare with children infection is usually mild. This overview illustrates the chickenpox and difference of immune response between the children and young adult toward infection with the varicella-zoster virus.