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SM Journal of Cardiology and Cardiovascular Diseases

Experimental Model of Oxidative Stress Markers in Subclinical Atherogenesis Associated with Metabolic Syndrome

[ ISSN : 3068-0034 ]

Abstract
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Received: 27-Feb-2018

Accepted: 19-Mar-2018

Published: 26-Mar-2018

Research Article | Volume 4 - Issue 1 | Article DOI :

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Tarán Mariana D1, Baez María C1-3, María de La Paz Scribamo Parada1, Ariel Balceda1, Blencio Sergio1, Binci Miriam2 and Moya Mónica1-3*

1Faculty of Medical Sciences, Universiad Nacional de Córdoba, Argentina

2Faculty of Clinical analysis, Laboratorio LABAC, Argetina

3Faculty of Medical Sciences, Universiad Nacional de La Rioja, Argentina

Corresponding Author:

Moya Mónica, MD, PhD Professor of Biomedical Physics, Cardiovascular Biomarkers Laboratory, Los Médanos 3155, Alto Verde, 5009, Córdoba, Argentina, Tel/Fax: 54-351-4332020

Keywords

Biomarkers; Oxidative stress; Metabolic syndrome; Subclinical atherogenesis

Abstract

The study of oxidative markers in an experimental model of atherogenesis induced by Hyperfibrinogenemia (HF) and Metabolic Syndrome (MS) proposes to analyze the relationship between inflammatory biomarkers and oxidative stress associated with insulin resistance to determine their involvement in ischemic vascular lesions and explain the potential pathophysiological mechanisms.

Methods: Seventy two male Wistar strain rats were divided in six groups: control (A), HF for 30 days (B) and HF for 60 days (C), rats with MS (D), HF for 30 days+MS (E) and MS+HF for 30 days (F). Induction of HF to trigger the proinflammatory process is carried out by medium and paramedian laparotomies every seven days. For induction of the metabolic syndrome fructose 10% was administered diluted in the drinking water for 6 weeks. We determined plasma levels of insulin, glucose, triglycerides, HDL, fibrinogen, L-citruline and superoxide dimustase. Statistically analysed by an ANOVA,p<0.05 level of significance.

Results: The MS group (D) showed increased insulinemia, glucose and triglycerides with respect to group (A), (B) and (C) (p<0.001). Similiar modifications showed groups (E) and (F), with insulinemia, glucose and triglycerides increased with respect to (A) (p<0.01,p<0.001 respectively). HDL significantly decreased in the groups (D), (E) and (F) compared to control (p<0.001) and groups (B) and (C) (p<0.001)

Conclusion: The potential importance of vascular wall inflammation in diseases, subclinical atherosclerosis and MS, as a therapeutic target remains an area not yet fully explored, where new knowledge on the involvement of inflammatory mediators may be relevant as the score validated risk assessment does not currently include these components, and their inclusion could assess the actual risk patients.

Citation

Mariana TD, María BC, María de La Paz SP, Balceda A, Sergio B, Miriam B, et al. Experimental Model of Oxidative Stress Markers in Subclinical Atherogenesis Associated with Metabolic Syndrome. SM J Cardiolog and Cardiovasc Disord. 2018; 4(1): 1021.