Abstract
In all the previous research conducted on chylomicrons and their metabolidsm, the potential influence onto the formation and development of atherosclerotic and other changes in the body, the chylomicrons obtained by means of the cannuling of the ductus thoracicus are used exlusively in its abdominal part, immediately from or next to the cisterna chyli. So obtained chylomicrons present essentially a mixture of the particles of various sizes, chemical composition and superficial distribution of the lipid, cholesterol and protein phase, so that their averaged effects are always measured. Chylomicrons obtained from the serum, which are certainly not native chylomicrons, but their remnants, given the proved speed of their decomposition within the circulation. Another extremely important fact has not been researched yet, related to the cannuling of the ductus thoracicus, during which the mixing of chylomicrons with the lymph inflow is permanently disabled, as well as the inflow of chylomicrons and a large part of the lymph into the circulation. Thus, an organism is brought into the state of starvation, which probably leads to changes in the plasma lipoprotein metabolism. Such a situation may also have a retroactive effect on the generation and composition of the newly formed chylomicrons in the small intestine.This fact indicates significant shortcomings in the research of chylomicrons, in defining their potential role and impact on the generation of cardiovascular diseases, since the impact of the lymph and the lymphatic circulation has not been researched. The passage of chylomicrons through the lungs, and the potential impact of mastocytes on their final structure and composition at the moment of their entering the circulatory system has not been researched either. The passage of chylomicrons through ductus thoracicus and lungs can be considered a grey zone, an area which has not been researched yet, and which is to be thoroughly researched. Special attention is to be paid to the generation and role of large chylomicron particles, which I believe are the primary cause of the formation of atherosclerotic, and I hope there will be a research conducted in the future to confirm this.
Citation
KOCMUR BI. The Mechanism of the Emergence of Atherosclerosis, New Perspectives. SM J Cardiolog and Cardiovasc Disord. 2017; 3(3): 1013s2.