Keywords
Blood-Brain -Barrier; Diagnostic Agents; Amino Acids
Abstract
The fact that the brain is protected by the skull, the meninges and that the material which can enter is controlled by the Blood-Brain -Barrier (BBB) for bidirectional traffic is causing obstacles to the physicians in cases that remedy is needed for tumors, infections and dysfunction of the very complicated neuron cycles, billions of them, controlling all functions of life. Diagnosis is meeting great difficulties and nowadays only spectroscopy, with its latest development we can count the sound, which can give us the vague picture of what is happening inside the skull. Photo acoustic angiography is only one ultramodern way to understand the inner brain, two electrons fluorescence spectroscopy is also one of the method second to positron tomography. In all these cases, chemical agents are introduced to the sinner brain overcoming the BBB obstacle. Remedy by applying drugs is very often used either to cure tumors and infections and t5o repair neurologic dysfunction. The BBB is in all these cases a major issue to handle. In this mini review, we would like to update the reader on the confrontation with the BBB issue.
Citation
Shatzmiller S, Lapidot I and Zats G. Blood Brain Barrier Crossing OPEN for Therapeutic and Diagnostic Agents. SM J Neurol Disord Stroke. 2016; 2(2): 1012.