Keywords
Clear cell; Chondrosarcoma; Cytology; Immunohistochemistry; Fine-needle aspiration
Abstract
Clear cell chondrosarcoma (CCC) is a rare neoplasm. Reported here, is a case of a female patient with a history of marginal zone lymphoma of the thyroid presented with right hip pain. Magnetic resonance imaging (MRI) of the right hip revealed an abnormal signal, which subsequently was biopsied via fine-needle aspiration (FNA). The cellblock preparation from the cytology sample was further analyzed which revealed atypical chondroid cells with vacuolated cytoplasm, eccentric nuclei, and prominent nucleoli. The cellblock material showed fragments of nonmalignant bone and malignant chondroid cells with enlarged nuclei and prominent nucleoli in a background of multinucleated giant cells. Immunohistochemistry studies performed on cellblock cytology material ruled out other differentials such as malignant melanoma or metastatic epithelial tumor. These findings were consistent with the diagnosis of malignant cartilaginous tumor with features of CCC. Eventually the patient underwent surgical resection revealing a 5.0 x 4.0 – cm, white, cartilaginous mass with scattered fleshy areas involving the greater trochanter and extending into the intertrochanteric area. Histomorphologic features, together with immunohistochemistry (IHC) studies, confirmed the initial diagnosis of CCC made via cytology sample. Our case highlights how cytology material alone can be sufficient to provide a definitive diagnosis of CCC.
Citation
Khalil H, Bayram EN, Fletcher S, Nabati S, Asher N, et al. (2019) Clear Cell Chondrosarcoma Diagnosed by Fine Needle Aspiration: A Case Report with Brief Review of the Literature. JSM Clin Cytol Pathol 4: 4.