Keywords
Hypersecretory; Hyperplasia; Atypical; Malignant; Cystic
Abstract
Benign cystic hypersecretory hyperplasia and cystic hypersecretory duct carcinoma of the breast share similar histologic features including formation of cystically dilated ducts containing a homogeneous eosinophilic secretion that resembles thyroid colloid. However, cystic hypersecretory duct carcinoma of the breast is associated with proliferative malignant epithelium. Cystic hypersecretory lesions of the breast present with a varying morphologic features in the same mass. Strict histomorphologic criteria and confirmatory immunohistochemistry studies are essential for definitive diagnosis and appropriate management. We present a case where secretory proliferation of a breast mass displayed spectrum of changes from benign hyperplasia, to atypical hyperplasia, to frank ductal carcinoma in situ. Due to limited reported cases of these entities, little is known about the biological behavior, prognosis and molecular study of these lesions. By reporting more cases, we may reveal the biologic behavior of these uncommon lesions.
Citation
Bayram EN, Khalil H, Tsao T, Nathwani G, Pollard H, et al. (2019) Hypersecretory Hyperplasia of the Breast in a Non-pregnant Woman Showing a Histomorphologic Spectrum of Benign, Atypical, and Malignant Changes: Report of a Case and Brief Review of the Literature. JSM Clin Cytol Pathol 5: 3