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JSM Clinical Cytology and Pathology

Utility of Immunohistochemical Studies in Differentiating Diagnostically Challenging Radiation-Induced Atypia from Recurrent Squamous Cell Carcinoma: A Case Report and Literature Review, with a Proposed Algorithm for Differentiation

[ ISSN : 2689-1549 ]

Abstract
Details

Received: 30-Oct-2019

Accepted: 02-Dec-2019

Published: 03-Dec-2019

Case Report | Volume 1 - Issue 3 | Article DOI :

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raj Zanair Afzal¹, Irteza Afzal², Maham Afzal³, Dominik Dabrowski¹, Nicole Asher¹, and Mohamed Aziz¹*

¹ Department of Pathology, American University of the Caribbean, USA
² Department of Pathology, Shreveport Hospital, USA
³ York University, Canada

Corresponding Author:

Iraj Zanair Afzal, Department of Pathology, American University of the Caribbean, University Drive at Jordan Road Cupecoy, St. Maarten, USA, Tel: 216-504-6672; Email: iraj.afz94@gmail. com

Keywords

Radiation; Atypia; Squamous; Carcinoma; Immunohistochemical; Staining; Recurrent; Metastasis; Radiotherapy

Abstract

Radiation-induced atypia presents a diagnostic challenge in differentiation with squamous cell carcinomas of the upper aerodigestive tract and lung. It is imperative to understand the different features of radiation-induced atypia and differentiate it from squamous cell carcinoma. Immunohistochemistry (IHC) studies play an extremely important role in present-day pathology practice. It is being used for  diagnosis of primary and metastatic cancers, as a prognostic marker, targeted therapy, and identification of certain infectious agents. This case report discusses the features specific to each and proposes an IHC algorithm to assist in providing appropriate diagnosis and subsequent optimal management.

Citation

Afzal IZ, Afzal I, Afzal M, Dabrowski D, Asher N, et al. (2019) Utility of Immunohistochemical Studies in Differentiating Diagnostically Challenging Radiation-Induced Atypia from Recurrent Squamous Cell Car cinoma: A Case Report and Literature Review, with a Proposed Algorithm for Differentiation. JSM Clin Cytol Pathol 4: 6.