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SM Journal of Pharmacology and Therapeutics

Diabetes Mellitus-Islet Transplantation & Gene Therapy

[ ISSN : 2574-2396 ]

Abstract
Details

Received: 03-Jul-2017

Accepted: 15-Jul-2017

Published: 20-Jul-2017

Review Article | Volume 3 - Issue 1 | Article DOI :

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Ravikiran Panakanti* 

Department of Biopharmaceutical Sciences, Roosevelt University College of Pharmacy, United States

Corresponding Author:

Ravikiran Panakanti, Department of Biopharmaceutical Sciences, Roosevelt University College of Pharmacy, 1400 N. Roosevelt Blvd, SCH 250, Schaumburg, IL 60173, Illinois, United States, Tel: 847-330-4543; Email: rpanakanti@roosevelt.edu

Keywords

Adenoviral Vectors; Insulin; Diabetes mellitus; Islets of Langerhans

Abstract

Type-1 Diabetes mellitus is an autoimmune disorder that comprises around 10% of the current diabetic population. The only mode of therapy for type-1 diabetes is to administer insulin. However, it is becoming very challenging to control the homeostasis between insulin and glucose levels. Islets transplantation has the potential to become a cure for diabetes. However, primary non-function of the islet graft immediately following transplantation due to apoptosis triggered by hypoxia and pro-inflammatory cytokines is one of the major obstacles for the success of islet transplantation. Gene therapy can be beneficial for improving the outcomes of islet transplantation. This review summarizes the challenges facing islet transplantation and the various viral vectors that can be used to possibly overcome those challenges.

Citation

Panakanti R. Diabetes Mellitus-Islet Transplantation & Gene Therapy. SM J Pharmac Ther. 2017; 3(1): 1016.