Keywords
Piroxicam; Emulgel; Topical drug delivery system
Abstract
Emulgel (Emulsion in gel) have emerged as one of the most interesting topical drug delivery system as it has dual release control system i.e. emulsion and gel. Also the stability of emulsion is increased when it is incorporated in gel. Piroxicam is an orally or topically active NSAID. The objective of this work was to develop an emulgel for control delivery for Piroxicam. In present work we prepare emulsion and then incorporated in gel base. An attempt has been made to make use of three different gelling agents, which will release the drug effectively on the surface when it is applied topically. Twelve semisolid formulations belongs to HPMC, Poloxamer 407 and Carbopol 934 (0.5%w/w) were prepared and evaluated for various physicochemical parameters like physical appearance, pH, extrudability, drug content uniformity, spreadability and viscosity. In vitro drug release rate was determined through diffusion method using pre-hydrated cellophane membrane. Ex vivo studies were performed through rat skin by using Franz diffusion cell. The results of studies revealed that the optimized emulgel indicated 1-35 µm globule size. The pH were found is in the range of 6.7 (F11) to 7.4 (F2). The optimized formulation F2 showed good spreadability as well as maximum drug content. The optimized emulgel showed 75.6% release in 8 hours. The optimized emulgel showed drug permeation through rat skin up to 36.5%. Hence it can be concluded that emulsion based system is more effective and safe system for sustain delivery of NSAID(s).
Citation
Boda M, Chaurasia S and Vure P. Fabrication of Topical Piroxicam Emulgel: In Vitro and Ex Vivo Assessments. SM J Pharmac Ther. 2017; 3(2): 1018s.