Abstract
This study investigated potential correlation between the inflammatory marker, Calprotectin, and a S.O.S questionnaire from forty-nine Autistic children. Symptom and behavioral questionnaires were completed contemporaneously with stool sample collection. Mixed Model data analysis showed strong correlation between some questionnaire parameters and Calprotectin. ‘Need for a fixed routine’ was highly significantly correlated with Calprotectin (????<0.00009) with Multivariate Coefficient of 3.227, whilst paradoxically ‘constipation’ indicated significant change (????<0.02) with negative Multivariate Coefficient (-1.584). The negative ‘constipation’ appears to associate with the positive ‘need for a fixed routine’ indicating possibility of reciprocal, independent prediction of gastrointestinal inflammation. Results suggest that ‘need for a fixed routine’ and ‘constipation’ be included in a screening questionnaire as independent predictors of bowel dysfunction in these children.
Citation
Bramati-Castellarin I, Patel V and Drysdale IP. Faecal Calprotectin and a Twenty-Four-Parameter Questionnaire in Autistic Children with Gastrointestinal Symptoms. SM J Psychiatry Ment Health. 2017; 2(1): 1009.