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JSM Clinical Cytology and Pathology

Hybrid Schwannoma/Perineurioma: Case Report of a Diagnostically Challenging Uncommon Tumor and a Brief Review of the Literature

[ ISSN : 2689-1549 ]

Abstract
Details

Received: 04-Apr-2020

Accepted: 17-Apr-2020

Published: 19-Apr-2020

Case Report | Volume 2 - Issue 1 | Article DOI :

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Nicole DiTommaso¹, Christopher Taylor¹, Ibrahim El-Mais¹, Abdel Aziz Elsayed², Ali Aziz³, Alexander Garcia¹, and Mohamed Aziz¹*

¹ Department of Pathology, American University of the Caribbean, USA
² Ain Shams University, Cairo, Egypt
³ Drexel-Hahnemann University, PA, USA

Corresponding Author:

Nicole DiTommaso, Department of Pathology, American University of the Caribbean, 17 Judson Lane, Farmington, USA, Tel: 860-951-2412; Email: nicole.a.ditommaso@gmail.com

Keywords

Perineurioma; Schwannoma; Hybrid; Immunohistochemistry; Tumor; Benign; Malignant

Abstract

We report a case of a 26-year-old who woman presented with a 2.6 cm solitary slowly growing subcutaneous nodule covered by normally appearing skin on her left groin. The Original pathological examination of the mass was described as storiform-appearing cellular with slight subcutaneous fat infiltration positive CD34 immunostain. On second opinion the mass was described as well-circumscribed surrounded by a thin, membranous layer. Histomorphologic examination of the lesion described a storiform architectural pattern composed of spindle cells with plump nuclei, characteristic of Schwann cells. Further evidence of a schwannoma was supported by a positive S-100 stain along with the positive CD34 stain. However, an additional stain of epithelial membrane antigen (EMA) was positive, more consistent with a perineurioma. The clinicopathologic and immunohistochemical features of the lesion supported the diagnosis of a hybrid perineurioma/schwannoma, a unique form of peripheral nerve sheath tumors.

Citation

DiTommaso N, Taylor C, El-Mais I, Elsayed AA, Aziz A, et al. (2020) Hybrid Schwannoma/Perineurioma: Case Report of a Diagnostically Challenging Uncommon Tumor and a Brief Review of the Literature. JSM Clin Cytol Pathol 5: 3