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SM Journal of Medicinal Plant Studies

In-vitro Antimalarial and Antileishmanial Studies of Markhamia platycalyx Sprague Leaves

[ ISSN : 2638-4698 ]

Abstract
Details

Received: 31-Jul-2017

Accepted: 26-Aug-2017

Published: 01-Sep-2017

Basma Khalaf Mahmoud¹, Ashraf Nageeb El-Sayed Hamed¹*, Mamdouh Nabil Samy¹, Amira Samir Wanas¹,², Mohamed M. Radwan², Mahmoud A. ElSohly²,³, Mohamed Salah Kamel¹

¹Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
²National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
³Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA

Corresponding Author:

Ashraf Nageeb El-Sayed Hamed, Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt, Tel: +2086-234-77-59; Fax: +2086-236-90-75;

Keywords

Markhamia platycalyx; Bignoniaceae; In-vitro; Antimalarial; Antileishmanial

Abstract

Bignoniaceae is rich in active metabolites and includes numerous genera of high economic and therapeutic values. One of these plants is Markhamia platycalyx. The petroleum ether fraction of the total ethanol leaf extract of M. platycalyx exhibited IC50 26760 ng/mL against Plasmodium falciparum D6 and 22430 ng/mL against P. falciparum W2 in the 2nd phase assay. It did not show any cytotoxic activity against the VERO mammalian cells, indicating the safety of the petroleum ether fraction. Additionally, the dichloromethane fraction of the same extract was the most active fraction against Leishmania donovani amastigotes in THP1 with 86% inhibition in the 1ry phase assay, which was higher than Amphotericin B.

Citation

Mahmoud BK, Hamed ANE, Samy MN, Wanas AS, Radwan MM, ElSohly MA, et al. In-vitro Antimalarial and Antileishmanial Studies of Markhamia platycalyx Sprague Leaves. SM J Med Plant Stud. 2017; 1(1): 1002.