Keywords
Ovarian Cancer; Granulosa Cell Tumor; Metastasis; Bone; Clavicle; Tumor Recurrence; Fine-Needle Aspiration; FOXL2
Abstract
Ovarian granulosa cell tumor (GCT) is the most common malignant sex cord–stromal tumor, representing 2% to 3% of all ovarian cancers. It is generally considered to have a good prognosis with late recurrence typically occurring 5 to 20 years later. The majority of these tumors are locally aggressive and recur in the abdomen, pelvis, or lymph nodes. Distant metastases have been reported, particularly to the lung and liver, bone metastases are extremely rare and reflect hematogenous spreading. We present a case of a 60-year-old woman who was found to have an isolated lytic lesion in the right medial clavicle. The clavicle lesion proved to be a metastatic GCT with recurrence 20 years later. There are only a few GCTs with bone metastases reported in the literature and to the best of our knowledge this is the first reported metastasis to the clavicle bone.
Citation
Asher N, Chan M, Leonard S, Rountree C, Aziz M (2020) Meta static Ovarian Granulosa Cell Tumor to the Clavicle Bone Twenty Years After Primary Diagnosis: A Case Report and Literature Review. JSM Clin Cytol Pathol 2(3): 4.