Keywords
Myxoid liposarcoma; pregnancy; STSG; Split thickness skin graft
Abstract
Background: Liposarcomas in pregnancy are peculiar clinical scenarios that are continuously being reported in the English literature for their rarity, challenges in management and speculations of association between pregnancy and disease kinetics. Most cases reported are with liposarcomas in the retroperitoneum. We here add another case whose lesion is at left thigh with optimal tumor excision and split-thickness skin graft reconstruction to augment both prognosis and aesthetics. A literature review for cases reported after 2000 will be presented.
Method: Case report and literature review.
Results: A 33-year-old female with left thigh tumor noted 1 year prior to her second pregnancy found the lesion growing in size at 18 weeks of gestation. Characteristics of the tumor included soft, elastic, fixed, painless, without discharge or discoloration, and sized about 5x5cm. Myxoid liposarcoma was diagnosed under histological examination after tumor biopsy under local anesthesia. She soon received complete tumor resection with free margins confirmed, followed by split-thickness skin graft reconstruction of the wound to meet cosmetic concerns. She currently continues with her pregnancy uneventfully and no tumor recurrence is observed. A literature search on Pubmed using keywords with sarcoma and pregnancy found 6 entries prior to the current study after year 2000. Patient characteristics, diagnosis modality, pathology histology subtypes, maternal and fetal outcomes are organized and presented.
Conclusion: Liposarcoma in pregnancy is rare but deserves practitioners’ attention, for early detection and proper surgical management could greatly improve disease outcomes. Life-long surveillance after surgery is also important for local recurrence rate is high. Further studies for the interplay of growth hormones and sex hormones during pregnancy and their effects on soft tissue sarcomas are called for, as they might be of valuable treatment or prevention bases.
Citation
Ker CR, Chen CC, Huang SH, Kao CN and Shen CJ. Myxoid Liposarcoma at Thigh during Pregnancy: A Case Report and Literature Review. SM J Sarcoma Res. 2017; 1(1): 1005.