Chloe Fidanzi-Dugas¹, David Yannick Leger¹, Guillaume Chemin¹, Aurelie Perraud², Claire Carrion³, Claude-Yves Couquet⁴, Robert Granet¹, Vincent Sol¹ and Bertrand Liagre¹*
¹Laboratoire de Chimie des Substances Naturelles, Université de Limoges, France
²Homeostasie Cellulaire et Pathologie, Université de Limoges, France
³CIM, UMR CNRS 7276, Université de Limoges, France
?Laboratoire de recherche et d’analyse de la Haute-Vienne, Avenue du Professeur Joseph de Leobardy, 87005 Limoges, France
Corresponding Author:
Bertrand Liagre, Laboratoire de Chimie des Substances Naturelles, Universite de Limoges, France, Tel: 05-55-43-58-39; Fax: 05-55-43-58-39; Email: bertrand. liagre@unilim.fr
Abstract
To determine potential mechanisms by which PpIX-PA (protoporphyrin IX-polyamines; PpIX is coupled with two molecules of spermidine (PpIX-dSd) or spermine (PpIX-dSm)) inhibited prostate cancer cell viability, we studied its effects on mitochondrial membrane potential because alterations in mitochondrial structure and function have been shown to play a crucial role at early stages of apoptosis.
Citation
Fidanzi-Dugas C, Leger DY, Chemin G, Perraud A, Carrion C, Couquet CY, et al. Photodynamic Therapy on Prostate Cancer by Using New Photosensitizers, Protoporphyrin IX-Polyamine Derivatives. SM J Sarcoma Res. 2017; 1(1): 1002
