Keywords
Breast cancer; Neoplasm; Squamous cell carcinoma; Metaplastic carcinoma; Fine needle aspiration; Sentinel lymph node; Axillary lymph node; Prognosis; Treatment; Chemotherapy; Radiotherapy
Abstract
While breast cancer is the most prevalent form of cancer in women worldwide, the rare and aggressive subtype of primary squamous cell carcinoma of the breast represents an area of unmet need in breast cancer diagnosis and management. Currently, there is no agreed consensus on primary treatment options, neoadjuvant and adjuvant therapy, or prognosis of this rare type of carcinoma. In addition, definitive diagnosis of this entity represents a significant diagnostic challenge and strict criteria should be applied to make such diagnosis. We present a case of a 78-year-old female who presented to her physician with a left breast mass. The final diagnosis proved to be a primary squamous cell carcinoma of the breast. Here, we discuss and detail the diagnostic criteria and what we currently know regarding possible management options. It is our hope that this report raises awareness of clinicians and pathologists to this uncommon entity and promotes continued investigation to drive further development of efficacious diagnosis and safe treatment options to improve patient outcomes.
Citation
Azevedo C, Pokima N, Koppika M, Rushing E, Rodriguez K, et al. (2019) Primary Squamous Cell Carcinoma of the Breast with Metastasis to the Lung: A Case Report of a Rare and Aggressive Breast Cancer with Literature Review. JSM Clin Cytol Pathol 4: 5.